Abstract
Combination formulation of ampicillin and cloxacillin sodium is β-lactam antibiotic. They are amino penicillin–isoxazyl penicillin combination drugs. In HPLC method development was carried out with acetonitrile: phosphate buffer pH 5 (35:65), hypersil C18, 250X4.6mm, 5μm column, UV detector at 254nm and flow rate of 1ml/min. Ampicillin retention time is 3.130min and cloxacillin retention time is 7.907min. In capsule brand no.:1. ampicillin content is found to be 250.29mg i.e. 100.1% and cloxacillin content is found to be 252.01mg. i.e. 102.75%. Validation results obtained are satisifactory for accuracy, precision, limit of detection, limit of quantification, linearity, system suitability, ruggedness and robustness parameters.
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