Abstract
We report a new, sensitive, fast, precise, reversed phase-high performance liquid chromatography method for the determination of flurazepam in (capsule) dosage form. The developed method is validated by measuring the linearity, precision, limit of detection (LOD), robustness and ruggedness, drug recovery and the system suitability parameters. The HPLC conditions are; methanol:acetonitrile (80:20 v/v) mobile phase, Chromosil C 18 column (250 mm × 4.6 mm × 5 μm) stationary phase, pump pressure (6.5 MPa), flow rate (0.9 ml/min) and the detection wavelength of 230 nm. The measured flurazepam retention time is 5.27 minutes. The limit of detection is 0.05 μg/ml. The linearity range measured is from 20-200 μg/mL with a correlation coefficient (R 2 =0.9991). The measured parameters indicate the developed method is useful in determination of flurazepam in pure and capsule dosage form.
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