Abstract
The accurate, precise, sensitive and economical HPLC method was developed and validated for simultaneous estimation of Ilaprazole and Levosulpirde in capsule dosage form. The quantification was carried out using mobile phase comprised of 10 mM Ammonium acetate in water, pH 5.0: Diluent in proportion of ratio 45:55%v/v degassed under ultra- sonication. The flow rate was adjusted to 1 ml/min. The method was validated in terms of linearity, precision, accuracy and specificity, limit of detection and limit of quantification. Linearity of Ilaprazole and Levosulpiride were in range of 1-20 µg/ml and 7.5-150 µg/ml respectively. The retention time of Ilaprazole and Levosulpiride were 5.21 and 9.2 respectively. The percentage recoveries of both drugs were found to be 99.3% and 99.18% for Ilaprazole and Levosulpiride respectively from the capsule formulation. The proposed method enables rapid quantification and simultaneous analysis of both drugs from commercial formulations without any excipients interference.1
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