Abstract
Mitsugumin 53 (MG53), a tripartite-motif (TRIM) family protein, participates in cell membrane repair in multiple cell types. MG53 protects myocardial infarction associated with ischemia-reperfusion injury. Subcutaneous injection of purified MG53 to a mouse model of Duchenne muscular dystrophy alleviates the muscle pathology by promoting membrane repair. We previously reported the role of MG53 in mouse skeletal myotubes - MG53 binds to sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 1a (SERCA1a) via its TRIM and PRY domains, and attenuates SERCA1a activity. In the present study, we tried to find additional roles of MG53 in skeletal muscle using single skeletal myotube Ca2+ imaging experiment, and found that MG53 regulated Ca2+ homeostasis in skeletal myotubes.
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