Abstract
Common inflammatory skin diseases such as psoriasis,atopic dermatitis and contact dermatitis are characterized by typical skin inflammation represented by infiltrating T lymphocytes.Chemokine CCL27,with CCR10 as its only receptor,is mainly produced by keratinocytes.Since CCL27-CCR10 interactions can induce skin memory T cells to migrate to the local skin,thus to form and maintain a variety of inflammatory skin lesions,they have become a new target for drug development.Although there has been no practical clinical medicine,the favorable outcomes in studies in vivo and in vitro do open a new door for the treatment of inflammatory skin diseases with anti-CCL27 antibodies or CCR10 antagonists. Key words: Inflammation; Skin diseases; Chemokine CCL27
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