Research progress on common related diseases of Malassezia

Abstract

There are many resident bacteria and conditioned pathogens on the skin surface of human body. Malassezia pachydermatis is one of the most common bacteria. Many skin diseases, such as tinea versicolor, Malassezia folliculitis, seborrheic dermatitis, atopic dermatitis, psoriasis and so on, are closely related to the colonization of Malassezia pachydermatis. The incidence of these common skin diseases is very high and the high incidence areas are mostly distributed in the tropics and subtropics. And many diseases are often recurrent, accompanied by obvious itching symptoms, unbearable, seriously affect the psychological and physical health of patients, so it is particularly important to understand the role of Malassezia pachydermatis in these diseases. Studies have shown that Malassezia pachydermatis is a part of the normal skin flora, it has a regular interaction with skin immune cells such as dendritic cells or lymphocytes. We can detect Malassezia pachydermatis specific immunoglobulin G and immunoglobulin M in healthy people. In contrast, the detection rate of Malassezia pachydermatis specific immunoglobulin E in healthy people is very low or even undetectable, and most of the atopic dermatitis patients are more sensitive to this yeast. It can be draw a conclusion that Malassezia pachydermatis may be associated with the development of atopic dermatitis, but the specific relationship is not clear. This review summarizes the pathogenesis of Malassezia pachydermatis in common related skin diseases, which focuses on the research progress of Malassezia pachydermatis in the pathogenesis of atopic dermatitis. Key words: Malassezia; Tinea versicolor; Folliculitis; Seborrheic dermatitis; Atopic dermatitis