ROLE OF RIGHT VENTRICULAR–PULMONARY ARTERY COUPLING IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION

Abstract

Objectives: To describe the clinical characteristics, right ventricular pulmonary artery (RV-PA) coupling and assess the correlation between RV-PA coupling and six-minute walk distance (6-MWD) in patients with heart failure with reduced ejection fraction (HFrEF). Subjects and methods: A prospective study with 39 patients with heart failure with HFrEF was recruited at 108 Central Military Hospital from December 2022 to October 2023. Results: A total of 39 patients were enrolled to the study with a majority of male (76.9%), mean age 63.7±15.7 years. Based on univariate and multivariate analysis, there is no correlation between right ventricular pulmonary artery coupling and 6-MWD, as evidenced by parameters including TAPSE/PASP (r=0.111, β=37.09, p=0.499), FAC/RVSP (r=0.012, β=1.29, p=0.944), and S’/RVSP (r=0.216, β=105, p=0.186). Nevertheless, there is a negative correlation between FAC/RVSP and S'/RVSP with LAVi, with respective values of (r = -0.522, β = -11.97, p-value = 0.001) and (r= -0.487, β = -0.005, p-value = 0.002). Conclusion: RVPAc cannot be used to predict exercise in HFrEF. Among echocardiographic RVPAc ratios, FAC/RVSP and S'/RVSP are correlated with left atrial volume index.