Abstract
Event Abstract Back to Event Role of reactive astrocytes and gliotransmitters in neurodegenerative diseases Changjoon J. Lee1* 1 Brain Science Institute, KIST, Center for Neuroscience and Functional Connectomics, Republic of Korea Brain is composed of not only neurons but also glia. It has been recently established that in addition to neurons, glial cells can release various transmitters (termed gliotransmitters), such as GABA, glutamate, and d-serine. The functional significance of these gliotransmitters is beginning to unravel as the detailed mechanisms of release have become available. We have recently demonstrated the role of GABA, synthesized via MAO-B and released through GABA-permeable Best1 channel from reactive astrocytes, in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. During the course of these studies, we have developed various molecular tools, mouse and rat models, and neural probes to address specific questions in animal models of neurodegenerative diseases. These newly developed targets and tools will prove useful in developing novel therapeutics for various neurodegenerative diseases that currently have no cure for. Keywords: Astrocytes, Alzheimer, GABA, neurodegeneration, MAO-B Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Plenary Lecture 4 Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Lee CJ (2016). Role of reactive astrocytes and gliotransmitters in neurodegenerative diseases. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00004 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Jul 2016; Published Online: 11 Aug 2016. * Correspondence: Prof. Changjoon J Lee, Brain Science Institute, KIST, Center for Neuroscience and Functional Connectomics, Seoul, Seoul, Republic of Korea, cjl@kist.re.kr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Changjoon J Lee Google Changjoon J Lee Google Scholar Changjoon J Lee PubMed Changjoon J Lee Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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