Abstract
Coronavirus disease 2019 (COVID-19) was declared a pandemic at the beginning of 2020, causing millions of deaths worldwide. Millions of vaccine doses have been administered worldwide; however, outbreaks continue. Probiotics are known to restore a stable gut microbiota by regulating innate and adaptive immunity within the gut, demonstrating the possibility that they may be used to combat COVID-19 because of several pieces of evidence suggesting that COVID-19 has an adverse impact on gut microbiota dysbiosis. Thus, probiotics and their metabolites with known antiviral properties may be used as an adjunctive treatment to combat COVID-19. Several clinical trials have revealed the efficacy of probiotics and their metabolites in treating patients with SARS-CoV-2. However, its molecular mechanism has not been unraveled. The availability of abundant data resources and computational methods has significantly changed research finding molecular insights between probiotics and COVID-19. This review highlights computational approaches involving microbiome-based approaches and ensemble-driven docking approaches, as well as a case study proving the effects of probiotic metabolites on SARS-CoV-2.
Highlights
The ongoing onslaught of the COVID-19 pandemic has threatened human life and health with a catastrophic impact on global financial and medical burdens [1]
The alteration of intestinal flora composition has been reported for COVID-19 patients (Figure 2). These findings suggest the importance of understanding the gut-lung axis (GLA) for the management of COVID-19
Metagenomics sequencing carried fecal DNA samples obtained from COVID-19 patients, resulting in a significant difference between gut microbiome of healthy controls and patients, for some gut commensals such as Faecalibacterium prausnitzii and bifidobacteria, which were underrepresented in COVID-19 patients [68]
Summary
Quang Vo Nguyen 1 , Li Chuin Chong 2 , Yan-Yan Hor 3 , Lee-Ching Lew 4 , Irfan A.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call