Role of Probiotics in Enteric Disease Management And Their Antivirulence Properties

Abstract

Probiotics have been the core area of study since last few decades due to their immense beneficial effects on human health. They are widely incorporated as a verity of products in food industry. Prebiotics are the commonly used fibers and when used in combination with probiotics are called as synbiotics, thus enhancing the probiotic activity. Several in vitro and in vivo studies have revealed the application of these microbiota management tool for the prevention and cure of diseases. Diarrhea prevention, atopiceczema, dental care, cancer therapy and treatment of bowel syndrome are the various health benefits provided by probiotic activity. These wonderful microorganisms have the enzymatic activity of breakdowning the food macromolecules, secretion of anti rnicrobial substances, anti-carcinogenicability, enhancing immune system, improved ability in producing short-chain fatty acid, anti atherogenicability, allergen regulation, anti-virulence activity, treatment of urinary tract infections and many more. In the light of this remarkable ongoing trend and the scientific evidence obtained on these microbiota, it is the need of hour to do further research on dose and optimal probiotic for specific diseases. This narrative review present the current documentation on enteric disease management stratagies and antivirulence studies focusing on quantum sensing inhibition, anti-toxin effects and anti-invasion effects.