Abstract
ObjectivesAntiepileptic drugs (ADEs) are now used to treat a wide range of neurological problems, although their usage is still restricted due to their side effects, particularly hepatotoxicity. Thus, this study consists of the therapeutic effects of non-conditioned Mesenchymal Stem Cells (MSCs) and the MSCs preconditioned with cherry extract (MSCs CM) on mitigation of liver damage induced by the dual administration of antiepileptic drugs such as Levetiracetam (L) and Oxcarbazepine (O). MethodsThe toxicity was induced in male albino rats by the means of the ADEs administration and was examined with the help of different paraments such as biochemical (total protein, albumin, globulin levels, A/G ratio level ALT, and GGTP), Oxidative stress (MDA, NO, and GSH), western blotting assay, immune-histopathology, and histopathological examinations. ResultsThe results revealed that rats treated with LO showed an increase in the level of ALT, GGTP, MDA, NO, Bax, and the protein expression of AKT and BI3K, caspase 3 level along with a decrease in GSH, total protein, albumin levels as well as, the level of Bcl2. MSCs or MSC CM with cherry extract treatment post antiepileptic drug administration ameliorate these parameters. Our findings suggest that MSCs and MSCs CM could be used in the disparity purpose of dual antiepileptic drugs induced towards normal. ConclusionsThus, it may be deduced that MSCs and MSC CM can hepatoprotection against ADEs-mediated hepatotoxicity and hence signifying that they could be a used as a valuable natural remedy for treating liver damage caused by drugs.
Published Version
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