ROLE OF LIPID AND LIPOPROTEIN IN FEMALE BREAST CANCER PATIENTS

Abstract

Introduction:The lipid prole status among breast cancer patients at initial diagnosis and during chemotherapy remains controversial. The aim of this study is to study the status of lipid and lipoprotein in female breast cancer patients at initial diagnosis and during chemotherapy. Methods: We conducted a retrospective cohort study of the status of the lipid and lipoprotein in 1054 primarily diagnosed breast cancer patients and 2483 normal controls with age stratication, from July 2015 to October 2016. At the same time, the status of lipid and lipoprotein were also analyzed among 250 breast cancer patients before and after adjuvant chemotherapy. Results: The incidence of dyslipidemia was signicantly lower in breast cancer group (41.82%) compared to normal group (55.26%) (P < 0.001). The levels of total cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C) among breast cancer group were signicantly lower compared to normal control group (P < 0.05). With age stratication, the levels of TC and LDL-C in breast cancer group were still signicantly lower than those in control group (P < 0.001). And the levels of TC, TG, LDL-C, apolipoprotein B were signicantly higher among post chemotherapeutic patients compared to prechemotherapeutic patients, however HDL-C and Apo-A1 levels were contrary. Conclusions: Breast cancer patients have lower incidence of dyslipidemia compared to normal populations. However, the situation of dyslipidemia may become worsened after chemotherapy. Therefore, lipid monitoring and dyslipidemia prevention and treatment should be conducted for breast cancer patients at initial diagnosis and during chemotherapy.