Abstract
BackgroundThe lipid profile status among breast cancer patients at initial diagnosis and during chemotherapy remain controversial. The aim of this study is to study the status of lipid and lipoprotein in female breast cancer patients at initial diagnosis and during chemotherapy.MethodsWe conducted a retrospective cohort study of the status of the lipid and lipoprotein in 1054 primarily diagnosed breast cancer patients and 2483 normal controls with age stratification, from July 2015 to October 2016. At the same time, the status of lipid and lipoprotein were also analyzed among 394 breast cancer patients before and after adjuvant chemotherapy.ResultsThe incidence of dyslipidemia was significantly lower in breast cancer group(42.98%) compared to normal group(58.28%)(P < 0.001). The levels of total cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C) among breast cancer group were significantly lower compared to normal control group (P < 0.05). With age stratification, the levels of TC and LDL-C in breast cancer group were still significantly lower than those in control group (P < 0.001). And the levels of TC, TG, LDL-C, apolipoprotein B were significantly higher among post chemotherapeutic patients compared to prechemotherapeutic patients, however HDL-C and Apo-A1 levels were contrary.ConclusionsBreast cancer patients have lower incidence of dyslipidemia compared to normal populations. However, the situation of dyslipidemia may become worsened after chemotherapy. Therefore, lipid monitoring and dyslipidemia prevention and treatment should be conducted for breast cancer patients at initial diagnosis and during chemotherapy.
Highlights
The lipid profile status among breast cancer patients at initial diagnosis and during chemotherapy remain controversial
A study suggested that higher mammographic density considered to be a strong risk factor of breast cancer [7], which is associated with increased HDL cholesterol (HDL-C) levels and decreased low-density lipoprotein-cholesterol (LDL-C) levels [8]
In this study, we demonstrate that the incidence of dyslipidemia in breast cancer patients (42.98%) was significantly lower than that in control group(58.28%,P < 0.001), and the total serum levels of cholesterol, triglycerides, HDL-C and LDL-C are significantly lower in breast cancer patients than those in normal controls in southwest of China
Summary
The lipid profile status among breast cancer patients at initial diagnosis and during chemotherapy remain controversial. The aim of this study is to study the status of lipid and lipoprotein in female breast cancer patients at initial diagnosis and during chemotherapy. A study suggested that higher mammographic density considered to be a strong risk factor of breast cancer [7], which is associated with increased HDL-C levels and decreased LDL-C levels [8]. Some prospective clinical studies reported that high levels of TC and HDL-C may increase breast cancer incidence [9,10,11]. The aim of this study is to investigate the status of serum lipids and lipoproteins in breast cancer patients and normal controls and their changes during chemotherapy
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