Abstract
The role of inflammation in the pathogenesis of atherosclerotic lesion in CHD is widely discussed. In the study the relationship between the production of cytokines IL1, IL4, IL10, TNFα and clinical variations of ischemic heart disease has been studied. Patients with ischemic heart disease with stable and unstable angina were examined. The level of production of cytokines in blood serum was determined by immunoenzyme analysis. Studies show strong evidence for the participation of cytokines in immune inflammation mechanisms in coronary heart disease. The high functional class of angina accompanied by hyperproduction of pro-inflammatory cytokines dictates the need to develop new therapeutic approaches to reduce the production of proinflammatory cytokines in order to reduce the progressive inflammatory process and prevent the transition to an unstable form of the disease.
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