Abstract
ObjectiveTo evaluate the association of human papilloma virus (HPV) infection with prognosis, specifically overall survival (OS) and disease‐free survival (DFS), in laryngeal squamous cell carcinoma (LSCC) patients.MethodA systematic review and meta‐analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. LSCC was confirmed on the basis of histopathology, whereas HPV status was confirmed by polymerase chain reaction.ResultsA total of 6539 articles were initially searched from 8 databases, of which 11 studies were eligible for our review. A total of 1442 LSCC cases were included in this analysis. Eight studies examined 3‐year OS for LSCC. The pooled hazard ratio (HR) from the 8 studies was 0.29 (95% CI: 0.25‐0.33). There was a statistically significant difference in 3‐year OS between the HPV‐negative and ‐positive groups, with the latter having a better survival. There was no statistically significant differences in 5‐ and 10‐year OS. Five studies examined 3‐ and 5‐year DFS for LSCC, whereas only 3 studies examined 10‐year DFS. There was no statistically significant difference in 3‐, 5‐, and 10‐year DFS between the HPV groups.ConclusionThis study evaluated the survival impact of HPV infection in LSCC patients. The OS of the HPV‐positive group was better than that of the HPV‐negative group in terms of short‐term survival. Compared with the HPV‐negative group, the HPV‐positive group had a better trend of DFS, suggesting that a larger sample size and further exploration of the pathology and local control of HPV‐positive tumors are needed.
Highlights
Laryngeal squamous cell carcinoma (LSCC) represents one of the most common head and neck malignancies, accounting for approximately 20% of all cases, with up to 40% of patients presenting with advanced disease at the time of diagnosis
Human papillomavirus (HPV) infection is a cause of squamous cancers of the oropharynx,[2,3,4] and emerging evidence showed that human papilloma virus (HPV) infection may be associated with an increased risk of laryngeal squamous cell carcinoma (LSCC).[5]
Oropharyngeal cancers have been divided into two distinct diseases on the basis of HPV presence or absence, but there is no detailed stratification of HPV infection in LSCC
Summary
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request
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