Abstract
Heart failure is the terminal outcome of the majority of cardiovascular diseases, which lacks specific diagnostic biomarkers and therapeutic targets. It contributes to most of cardiovascular hospitalizations and death despite of the current therapy. Therefore, it is important to explore potential molecules improving the diagnosis and treatment of heart failure. MicroRNAs (miRNAs) are small non-coding RNAs that have been reported to be involved in regulating processes of heart failure. After the discovery of miRNAs in exosomes, the subcellular distribution analysis of miRNAs is raising researchers' attention. Growing evidence demonstrates that exosomal miRNAs may be promising diagnostic and therapeutic molecules for heart failure. This review summarizes the role of exosomal miRNAs in heart failure in the prospect of molecular and clinical researches.
Highlights
Heart failure is the terminal stage of various Cardiovascular diseases (CVDs), with sustaining high morbidity and mortality contributing most to cardiac death [1]
Cardiac fibroblasts secrete exosomes enriched with miR-21-3p, inducing cardiac hypertrophy by targeting recipient cardiomyocytes [19]
(3) Communications between other cardiovascular cell types and cardiomyocytes: Exosomes enriched with miR-155 which were derived from macrophages promoted cardiac hypertrophy and fibrosis by activating the prohypertrophic pathway FOXO3a in uremic mice [25]
Summary
Ruicong Xue , 1,2,3 Weiping Tan 4, Yuzhong Wu , 1,2,3 Bin Dong , 1,2,3 Zengshuo Xie , 1,2,3 Peisen Huang 1,2,3, Jiangui He 1,2,3, Yugang Dong 1,2,3* and Chen Liu * 1,2,3. Edited by: Christian Schulte, University Heart and Vascular Center Hamburg (UHZ), Germany. Heart failure is the terminal outcome of the majority of cardiovascular diseases, which lacks specific diagnostic biomarkers and therapeutic targets. It contributes to most of cardiovascular hospitalizations and death despite of the current therapy. It is important to explore potential molecules improving the diagnosis and treatment of heart failure. MicroRNAs (miRNAs) are small non-coding RNAs that have been reported to be involved in regulating processes of heart failure. Growing evidence demonstrates that exosomal miRNAs may be promising diagnostic and therapeutic molecules for heart failure. This review summarizes the role of exosomal miRNAs in heart failure in the prospect of molecular and clinical researches
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