Abstract
A snapshot of genetic and epigenetic basis of arrhythmia and heart failure.
Highlights
In this issue, genetic aspects of arrhythmia were described by 3 different groups. Crump and Abbott (2014) provided an update about arrhythmogenic KCNE gene variants and their roles, and discussed several challenges in this area
Yao et al (2014) gave an overview on the paired-like homeodomain 2, which was identified as a common variant to be involved in atrial fibrillation, highlighting the potential of paired-like homeodomain 2 as a new therapeutic target
Besides highlighting specific genetic mutations associated with heart failure, they summarized epigenetic mechanisms including DNA methylation, ATP-dependent chromatin remodeling, histone modification and RNA-based mechanisms, highlighting the relationship among epigenetics, heart failure and arrhythmiaogenesis
Summary
Genetic aspects of arrhythmia were described by 3 different groups. Crump and Abbott (2014) provided an update about arrhythmogenic KCNE gene variants and their roles, and discussed several challenges in this area. Yao et al (2014) gave an overview on the paired-like homeodomain 2, which was identified as a common variant to be involved in atrial fibrillation, highlighting the potential of paired-like homeodomain 2 as a new therapeutic target. Duygu et al (2013) provided an outstanding overview about the genetics and epigenetics of arrhythmia and heart failure.
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