Role of Etanercept Against Renal Damage Induced by Cecal Ligation and Puncture in Male Rats

Abstract

Cecal ligation and puncture (CLP) is one of the most widely utilized models for rat experimental polymicrobial sepsis. In this work, we examine how the anti-oxidant and anti-inflammatory drug Etanercept (ENT), which has been FDA-approved, might lessen the damaging effects of sepsis on renal tissues. In this study, rats were divided into four groups: the control group, which received just CLP; the solvent group, which received DMSO intravenously before CLP; and the treatment group, which received ENT intraperitoneally before CLP, might possibly reduce the risk of sepsis-induced renal tissue damage. According to our results, ENT reduced NF-kB, TNF-\(\alpha\), and TLR levels compared to the solvent alone group or control group. A positive tissue integrity was found in the ENT-pretreated group as compared to the solvent-only group or control group during a histopathological evaluation of the renal tissues. The findings indicate that ENT could potentially lower the risk of renal tissue damage due to CLP.