Comparison of Intralesional Injection of Hyaluronic Acid with Triamcinolone and Triamcinolone Alone in Treatment of Oral Lichen Planus at Tertiary care Oral & Maxillofacial Center

Abstract

Objective: To compare the outcome of intralesional injection of Hyaluronic acid with Triamcinolone and Triamcinolone alone in the management of Oral Lichen Planus. Methodology: This randomized controlled trial, conducted in the Oral & Maxillofacial Surgery department at Punjab Dental Hospital(PDH), Lahore, included 30 patients aged 20-70 years with histopathologically confirmed Oral Lichen planus (0.5-4 cm), using a Split mouth technique. One side of the lesion received intralesional Triamcinolone (40 mg/ml), while the other side received a combination of Hyaluronic acid and Triamcinolone. Pain and lesion size were assessed using a Visual Analogue Scale and measured at 2 and 12 weeks. Data was analyzed in SPSS version 20.0, with significance at P < 0.05, comparing mean pain scores and lesion disappearance between groups using t-tests and Chi-square tests. Results: Total 30 patients were included. The mean age of the patients was 48.76±14.67 year. Oral health assessment revealed that 9(30%) patients had good oral hygiene, and 15(50%) average hygiene. At baseline and 2nd week mean pain score in Intervention group was 5.7±1.08, 1.60 ±0.62 and in control patients was 5.6±1.03 and 2.10±0.99. Disappearance of lesion showed no significant difference between groups. Although in intervention group rate of disappearance of lesion was higher. i.e. Intervention: 73.3% vs. Control: 50%, p-value=0.063 Conclusion: The conclusion of the study is that intralesional injection of Hyaluronic acid plus Triamcinolone is more effective than Triamcinolone alone for treating Oral Lichen Planus in terms of pain reduction and lesion disappearance