Abstract
Role of Bilirubin and Albumin in Cord Blood as Predictors for Neonatal Hyperbilirubinemia
Highlights
Hyperbilirubinemia is the most common cause for readmission during the early neonatal period [2].Many efforts have been made to identify infants likely to develop neonatal jaundice
A cut off level of cord bilirubin/albumin ratio of 0.79 in our study was determined to have 83.3% sensitivity, 85.7% specificity and positive predictive value (PPV) 93.8% in the prediction of occurrence of significant hyperbilirubinemia in high risk group, with negative predictive value (NPV) 66.7%
We conclude from the results of our study ;that in the total group, the highest sensitivity (83.3%) was for cut off value of cord bilirubin (1.88mg/dl)with PPV 72.9%, which mean that we can predict 83.3% of patients with the disease but 16.7% of cases with the disease go undetected; whilst the highest specificity (84.8%) was for cut off value of cord bilirubinalbumin(-0.6)with NPV 74.1%,which mean that we can correctly report 84.8% of patients without the disease as test negative but 15.2% patients without the disease are incorrectly identified as test positive
Summary
Hyperbilirubinemia is the most common cause for readmission during the early neonatal period [2]. Many efforts have been made to identify infants likely to develop neonatal jaundice. Reliable strategies can reduce hospital stay for normal babies and identify significant hyperbilirubinemia that may happen in the future [3]. There have been a few studies which predicted postnatal hyperbilirubinemia by estimating cord blood bilirubin levels but vary in opinions [4,5,6]. Albumin binds with unconjugated bilirubin and protects against kernicterus [7]
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