Abstract
Positive Efficiency of Combine Immunotherapy in Immunocompromised Girls with Recurrent Nonspecific Chronic Vulvovaginitis
Highlights
Vulvovaginitis takes the first place in the structure of gynaecological disorders in girls of primary school age and preschool age, with the peak share at the age of 2-7 years old
Out of 25 examined girls suffering from recurrent active Nonspecific chronic vulvovaginites (NCVV) there were 14 girls with criterial clinical signs of immunodeficiency: recurrent ARVI occurring more than 10 times per year, frequent NCVV aggravations [8,12]
Taking into account the found defects in immune system (IS) functioning and IFN status in immunocompromised girls, we have developed a program of combined immunotherapy lasting for 2.5 months using local and system therapy with recombinant human interferon α2b combined with antioxidants (Viferon) and glucosaminylmuramyldipeptide (Licopid), which will be included into therapy to a limited extent
Summary
Vulvovaginitis takes the first place in the structure of gynaecological disorders in girls of primary school age and preschool age, with the peak share at the age of 2-7 years old. Acute and chronic genital inflammations in childhood may later cause serious infections and inflammations in women of various ages and result in reproductive disorders in women of childbearing age. At the age of 2 to 7 years old the immune protective mechanisms develop functionally, and they may cause immune system (IS) malfunctions under the influence of frequent ARVI, dysbiotic mucous disorders, functional disorders in organs and systems, chronic somatic and endocrine pathologies accompanied with immune deficiency – immunocompromised children [1,2]. Over 60% of vulvovaginitis in girls of primary school age and preschool age are recurrent and are caused by extragenital pathology aggravation. Recurrent vulvovaginitis are usually associated with inadequate therapy of both NCVV and extragenital pathology
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
