Role of antioxidant levelsand lipid peroxidationin patients with breast cancer

Abstract

Introduction and Aim:Breast cancer is main medical concerns with socio-economic significance especially for women. Various factors involved in the initiation, progression, and invasion of breast cancer oxidative stress plays an important role. Aim of the study designed to analyze the levels of antioxidants, and lipid peroxidation in breast cancer patients to identify the role of oxidative stress in breast cancer. Materials and Methods:Glucose profile, lipid profile and oxidative stress markers such as malondialdehyde(MDA), glutathione peroxidase(GPX), glutathione reductase(GR) and superoxide dismutase (SOD) levels were assessed in blood samples of both cases and controls. Data of all biochemical parameters of two groups were statistically analyzed by SPSS software. Results:Totally, 30 diagnosed breast cancer patients aged 35 to 70 years and age matched 30 healthy controls were enrolled. Levels of MDA were higher in breast cancer (9.91 ± 4) than control subjects (8.56 ± 3.6) with p value 0.17. SOD was significantly lower in breast cancer (9.4 ± 5.1) than control subjects (12.8 ± 5.7) with p value 0.018. GR levels were lower in breast cancer (12.7 ± 2.4) than control subjects (14.4 ± 4.6) with p value 0.7. GPX activity was lower in breast cancer (43.5 ± 10.5) than control subjects (44.7 ± 7.3) with p-value 0.6. SOD levels were significantly decreased in breast cancer (9.4 ± 5.1) than control subjects(12.8 ± 5.7) with p-value 0.018. Conclusion: High levels of lipid peroxidation with increased MDA is an important risk factor in the progression of breast cancer, which might be triggered by decreased antioxidant activity by suppressing the activity of GR, GPX, and SOD. Keywords: Breast cancer;oxidative stress;superoxide dismutase;lipid peroxidation