Abstract
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides a single access point to 44 RNA resources and >18 million ncRNA sequences from a wide range of organisms and RNA types. RNAcentral now also includes secondary (2D) structure information for >13 million sequences, making RNAcentral the world’s largest RNA 2D structure database. The 2D diagrams are displayed using R2DT, a new 2D structure visualization method that uses consistent, reproducible and recognizable layouts for related RNAs. The sequence similarity search has been updated with a faster interface featuring facets for filtering search results by RNA type, organism, source database or any keyword. This sequence search tool is available as a reusable web component, and has been integrated into several RNAcentral member databases, including Rfam, miRBase and snoDB. To allow for a more fine-grained assignment of RNA types and subtypes, all RNAcentral sequences have been annotated with Sequence Ontology terms. The RNAcentral database continues to grow and provide a central data resource for the RNA community. RNAcentral is freely available at https://rnacentral.org.
Highlights
RNAcentral is the non-coding RNA sequence database that currently integrates 44 specialist ncRNA databases, known as Expert Databases, to provide unified access to >18 million ncRNA sequences spanning a broad range of functions and species [1]
RNAcentral provides a wide range of annotation types, such as genome coordinates, microRNA–target interactions [2,3], Gene Ontology (GO) terms [4], orthologs and paralogs [5], RNA family classification from Rfam [6] and more
The primary goal of RNAcentral is to provide open access to a comprehensive set of ncRNA sequences for a wide range of species, enabling the users to find what is known about individual sequences or download ncRNA sequences and their genomic locations that can be used for a broad range of studies, such as interpreting the results of RNA-seq experiments or training bioinformatic algorithms
Summary
RNAcentral is the non-coding RNA (ncRNA) sequence database that currently integrates 44 specialist ncRNA databases, known as Expert Databases, to provide unified access to >18 million ncRNA sequences spanning a broad range of functions and species [1]. RNAcentral provides a wide range of annotation types, such as genome coordinates, microRNA–target interactions [2,3], Gene Ontology (GO) terms [4], orthologs and paralogs [5], RNA family classification from Rfam [6] and more. The primary goal of RNAcentral is to provide open access to a comprehensive set of ncRNA sequences for a wide range of species, enabling the users to find what is known about individual sequences or download ncRNA sequences and their genomic locations that can be used for a broad range of studies, such as interpreting the results of RNA-seq experiments or training bioinformatic algorithms. The previous NAR publication is marked with a vertical dashed line
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