Abstract
RNAcentral is a database of non-coding RNA (ncRNA) sequences that aggregates data from specialised ncRNA resources and provides a single entry point for accessing ncRNA sequences of all ncRNA types from all organisms. Since its launch in 2014, RNAcentral has integrated twelve new resources, taking the total number of collaborating database to 22, and began importing new types of data, such as modified nucleotides from MODOMICS and PDB. We created new species-specific identifiers that refer to unique RNA sequences within a context of single species. The website has been subject to continuous improvements focusing on text and sequence similarity searches as well as genome browsing functionality. All RNAcentral data is provided for free and is available for browsing, bulk downloads, and programmatic access at http://rnacentral.org/.
Highlights
Non-coding RNAs are a critical component of cellular machinery of all organisms
The ribosomal RNA has been shown to be a ribozyme responsible for peptide bond synthesis [1], and the activity of the eukaryotic spliceosome is mediated by ncRNAs [2]
We developed RNAcentral, a database of ncRNA sequences that serves as a single entry point to the data from a large collection of collaborating ncRNA resources that cover ncRNA sequences of all types and from all organisms
Summary
Non-coding RNAs (ncRNAs) are a critical component of cellular machinery of all organisms. RNAcentral aggregates ncRNA sequence data from an international consortium of RNA resources that we call Expert Databases.
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