Risk factors of posttraumatic cerebral infarction in patients with severe and extremely severe head injury

Abstract

Objective To explore pathogenesis and risk factors for posttraumatic cerebral infarction (PTCI) in patients with severe and extremely severe head injuries for the purpose of providing clues for reducing occurrence of PTCI and case - fatality.Methods Gender,age,Glasgow coma scale ( GCS),the presence or absence of basicranial fracture,cerebral hernia or infection,surgical modality,hypotension,and the use of diuretics and hemorheologic agents were recorded and analyzed in 62 PTCI patients ( study group) and 680 patients without PTCI (control group ) following severe and extremely severe head injuries.Results GCS,the presence or absence of cerebral hernia and/or infection,hypotension,the use of diuretics and hemorheologic agents were closely correlated with the occurrence of PTCI ( P ＜ 0.05 ).Conclusion GCS,the presence of cerebral hernia and infection,hypotension,and over - dosage of diuretics are common risk factors for PTCI,and the use of hemorheologic agents is a protective factor of PTCI in patients with severe and extremely severe head injuries. Key words: Posttraumatic cerebral infarction ; Logistic regression analysis ; Pathogenesis ; Risk factor ;