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Abstract
Changes in the base sequence of ribosomal RNA isolated from ribosomes in phosphate- or Mg 2+-deficient Escherichia coli were investigated. The frequency of purine tracts differed to various extents from that of rRNA obtained from normal cells. The purine tract distribution was determined by ribonuclease digestion followed by separation of the products by DEAE-cellulose chromatography. This difference from normal rRNA sequence was greater in the phosphate-deficient ribosomes from the wild strain than it was in those of Mg 2+-deficient wild stain or the phosphate deficient ribonuclease I-less mutant strain, Q-13. The size of the RNA's in intact ribosomes in these deficient states was normal as judged by sedimentation analysis and the total base composition of rRNA was slightly different from that in normal cells. The implication of the results is discussed proposing two possible hypothesis.
Published Version
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