Abstract
AbstractThe N-reverse prenylated indole motif is an important structure in natural products and biologically active molecules. Nevertheless, the direct N-reverse prenylation of nonactivated indoles is challenging. We report a rhodium-catalyzed regioselective N-reverse prenylation of indoles bearing various functional groups under neutral conditions. The triphenyl phosphite ligand and acetonitrile solvent together play a key role in the reactivity and selectivity.
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