Abstract

AbstractThe cross-coupling of two distinct C(sp3 )–O bonds provides a highly valuable pathway for the construction of C(sp3 )–C(sp3 ) bonds, but it remains underdeveloped. Recently, we reported an innovative photoinduced Zr-catalyzed carbomagnesiation for the reductive coupling of ethers with high cross-selectivity. Mechanistic investigation reveals that photoexcitation of low-valent zirconocene facilitates the activation of C(sp3 )–O bonds of benzylic ethers. This leads to the formation of functionalized benzylic Grignard reagents for downstream coupling with aliphatic ethers through an SN2-like pathway.1 Introduction2 Concept of Our Design on this Work3 Photoinduced Zr-Catalyzed Cross-Coupling of Ethers4 Photoinduced Zr-Catalyzed Cross-Coupling of Benzylic Magnesium Alkoxide with Ethers5 Our Methods for Mechanism Investigation6 Conclusion

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.