Abstract
Objective To investigate the clinical value of the combined detection of rheumatoid factor (RF), anti-cyclic citrullinated polypeptide (CCP) antibody, and anti-keratin antibody (AKA) in the diagnosis of rheumatoid arthritis (RA). Methods 85 RA patients treated at our hospital from January 2014 to September 2016 were randomly selected as an RA group. And 105 non-RA patients treated at our hospital during the same period were selected as a non-RA group. The RF in both groups was detected by radiofrequency turbidimetric method, the Anti-CCP antibody by enzyme-linked immunosorbent assay (ELISA), and the AKA by indirect immunofluorescence staining. The diagnostic results of each or the combination of the three were analyzed. Results The diagnostic efficiency of RF for RA was about 70.00%. The diagnostic specificities of AKA and anti-CCP for RA were 93.33% and 94.29%. The diagnostic sensitivities of AKA and anti-CCP for RA were 64.71% and 49.41%. The diagnostic sensitivity of the combination of the three was 29.41%. The diagnostic specificity of the combination of the three was 100.00%. The diagnostic accuracy of the combination of the three was 92.86%, which was higher than that of RF + anti-CCP (74.21%) and that of RF+AKA (69.47%) , with statistical differences (P<0.05) . Conclusions The three RA serological indicators, RF, anti-CCP, and AKA, each has some limitations in the diagnosis of RA; the combination of the three can increase the diagnostic accuracy and has great value in increasing the diagnostic specificity and can effectively reduce misdiagnosis and missed diagnosis. Key words: Rheumatoid arthritis; Anti-keratin antibodies; Anti-cyclic citrullinated peptide antibody; Rheumatoid factor; Combination detection
Published Version
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