Abstract
Abstract Rhabdomyomatous mesenchymal hamartoma (RMH) is a rare tumour-like lesion, which occurs in the skin of newborns, principally of the face and neck. RMH has also been reported in unusual sites, including oral cavity, nasal
Highlights
Rhabdomyomatous mesenchymal hamartoma (RMH) is a raretumour-like lesion, which occurs in the skin of newborns, principally of the face and neck [1-6]
We report a rare case of RMH arising as a nodular mass at the anal margin of a male newborn
The present case shows that RMH may occur at the anal margin, and that this possibility should be considered preoperatively by clinicians, as well as by pathologists when dealing with a pediatric ano-rectal lesion
Summary
Rhabdomyomatous mesenchymal hamartoma (RMH) is a raretumour-like lesion, which occurs in the skin of newborns, principally of the face and neck [1-6]. Apart from the skin of the head and neck region, RMH has been reported in unusual sites, including oral cavity [15-17], nasal vestibule [18] and vagina [19]. It can present as small dome-shaped papule or a polypoid pedunculated lesions [1-6,15-19]. We report a rare case of RMH arising as a nodular mass at the anal margin of a male newborn. Histological examination (Haematoxylin and Eosin staining) showed the typical features of RMH: a nodular mass, covered by normal-appearing epidermis, composed of a disordered admixture of dermal fascicles of mature skeletal muscle fibers, haphazardly intermingling with fibrous tissue, small islands of mature adipose tissue, adnexal glands, blood vessels of venular type, and small-sized nerves. Anti-desmin and anti-S100 protein antibodies were helpful in highlighting, respectively, all the skeletal muscle cells and small-sized nerves haphazardly distributed throughout the dermis (Figures 1B and 2B)
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