Abstract
Introduction Langerhans cell histiocytosis (LCH) integrates eosinophilic granuloma, Hand-Schüller-Christian disease, and Letterer- Siwe disease due to the proliferation of histiocyte-like cells, which have now been proved to be Langerhans cells [1,2]. The BRAF V600E mutation is an important genetic factor in LCH [3], and new terminology (inflammatory myeloid neoplasia) was introduced
Highlights
Langerhans cell histiocytosis (LCH) integrates eosinophilic granuloma, Hand-Schüller-Christian disease, and LettererSiwe disease due to the proliferation of histiocyte-like cells, which have been proved to be Langerhans cells [1,2]
Intralesional cytokines released from Langerhans cells and T cells are thought to play a role including in necrosis, especially in bone and other organs [9,10,11], but the cause of this necrosis, which is followed by a destructive process, remains unclear, and until now, the role of eosinophils has remained unclear
Check points were the number of lesions, the presence of Lung vascular destruction, the presence and numbers of cysts or Pathological characteristics of the 33 patients (22 men and cavities with pulmonary LCH are sumrial), the presence of degenerated cell shedding into the cavity, marized in Tables 1 and 2
Summary
Langerhans cell histiocytosis (LCH) integrates eosinophilic granuloma, Hand-Schüller-Christian disease, and LettererSiwe disease due to the proliferation of histiocyte-like cells, which have been proved to be Langerhans cells [1,2]. Nodular-shaped, single-system LCH is mainly composed of Langerhans cells and eosinophils histologically, and it was first named eosinophilic granuloma [6]. We have attempted to disclose the interrelationship of necrosis in LCH with eosinophilic degranulation from the pathologic aspect and have achieved this aim. Single-system Langerhans cell histiocytosis (LCH) shows massive infiltration of eosinophils and occasional necrosis and cyst/cavity formation, but the cause of the necrosis remains unclear.The role of eosinophils in necrosis in single-system LCH has not been examined yet, and ,we investigated their role pathologically
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