RF-Magnetron Sputtered Silica Interlayer on β-TCP Granules for Mesoporous Silica Coating

Abstract

Mesoporous silica (MPS) coatings on β-tricalcium phosphate (β-TCP) granules and their protein adsorptive capabilities were studied. β-TCP granules containing 2 wt% of aluminum oxide and 6 wt% of silicon oxide were prepared using a pan-type granulator and heated at 1200 oC. MPS coatings on β-TCP granules was carried out by a dip-coating method, but the β-TCP granules were not covered by the MPS particles. A silica interlayer was formed on the β-TCP granules via magnetron sputtering prior to the coating of the MPS. The β-TCP granules coated with the silica interlayer were fully covered by the MPS particles. A silica interlayer may offer bonding between the β-TCP granules and MPS coating. The adsorption of protein on the MPS-coated β-TCP granules was evaluated by UV-VIS spectroscopy. The adsorption capacity of protein on the β-TCP granules was improved by the MPS coatings on the β-TCP granules, and that of the β-TCP granules coated with the silica interlayer showed a higher protein adsorption capacity.