Silica Interlayer Formation of Mesoporous Silica Coatings on Hydroxyapatite Granules

Abstract

Mesoporous silica (MPS) coatings on hydroxyapatite (HAp) granules and their protein adsorptive capabilities were studied. MPS particles were coated on HAp granules using a dip-coating method, but the HAp granules were not totally covered by the MPS particles. A silica interlayer was formed on the HAp granules via magnetron sputtering or the sol-gel method prior to the coating of the MPS. The HAp granules coated with the silica interlayer were fully covered by the MPS particles. An silica interlayer may offer bonding between the HAp granules and MPS coating. The adsorption of protein on the MPS-coated HAp granules was evaluated by UV-VIS spectroscopy. The adsorption capacity of protein on the HAp granules was improved by the MPS coatings on the HAp granules, and that of the HAp granules coated with the silica interlayer showed a higher protein adsorption capacity.