Abstract
The influence of neuron mechanical deformation on the generation and propagation of the action potential is studied by revisiting the Hodgkin-Huxley (H-H) and the Fitzhugh-Nagumo (F-N) models within a coupled electromechanical framework. More specifically, effects of flexoelectricity and cellular membrane deformation on the kinetics of potassium channels are studied. Their activation and inactivation rate, as well as the appearance of time delay, are considered to describe changes in the propagation velocity of the action potential due to the axon deformation. The results obtained are supported by experimental evidence, although such phenomena are extremely challenging to analyze with existing tools. The electromechanical consideration of the generation and propagation of the action potential is a very promising field with important clinical implications and wide perspectives for further understanding the pathophysiology of various neurological disorders.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
