Retrospective analysis of nine pathogens infections in children with acute respiratory infection

Abstract

Objective To analyze the status and epidemiological characteristics of 9 pathogens infection in hospitalized children with acute respiratory infection. Methods From January 2011 to December 2014, a total of 23 498 children with acute respiratory infection were collected into this study. Indirect immunofluorescence assay was performed to detect immunoglobulin (Ig)M of 9 pathogens test in serum, including Mycoplasma pneumonia(MP), Legionella pneumophila(LP), Coxiella burnetii(COX), Chlamydia pneumoniae(CP), adenovirus(ADV), respiratory syncytial virus(RSV), influenza virus A(IFA), influenza virus B(IFB), and parainfluenza virus(PIV)]. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Maternal and Children Health Hospital of Guangxi Zhuang Autonomous Region. Informed consent was obtained from the parent of each participating child. Results ①Among 23 498 children, pathogen was identified in 10 525 children (44.79%), and one pathogen in 6 661 children (63.29%). The main pathogens were MP(37.37%), IFB(12.66%), and LP(6.06%). ②The positive rates in children aged under one year old, 1-3 years old and over 3 years old were 20.95%, 64.31% and 79.08%, respectively; and it were 54.71%, 39.88%, 45.05% and 43.34% from 2011 to 2014, respectively; and it were 45.37%, 38.59%, 44.91% and 50.08% in spring, summer, autumn and winter, respectively. There were statistically significant differences among different age periods, years and seasons (χ2=5 747.80, 182.41, 160.28; P<0.05). Conclusions MP, IFB, and LP were the main pathogens of hospital children with acute respiratory infection in Nanning. Key words: Respiratory tract infections; Acute disease; Pathogen; Epidemiology