Abstract
Two Co(II)-containing coordination polymers have been successfully prepared, and their treatment activity on the newborn bacterial acute sinusitis was evaluated and the related mechanism was explored as well. • Two new transition metal coordination polymers were prepared. • Complex 1 shows a 3D framework structure and complex 2 reveals a 2D layered network. • The application effect of compounds 1 and 2 on the bacterial acute sinusitis was estimated. Via applying a mixed-ligand approach, two new transition metal coordination polymers (CPs) [Co 3 (L) 2 (BPT) 2 (H 2 O) 4 ] ( 1 ) and [Co 2 (L) 2 (HBPT) 2 ]·H 2 O ( 2 ) have been constructed by reaction of the commensurable metal salts with the biphenyl-3,4′,5-tricarboxylic acid (H 3 BPT) with the presence of the V-shape N -donor linker 3-di(1 H -imidazol-4-yl)benzene (L). The structural characterization results show that complex 1 shows a 3D framework structure with a (4,4)-connected topological network and complex 2 reveals a 2D layered network which is further extended into the 3D supramolecular network via the H-bond interactions. Furthermore, the treatment activity of compounds 1 and 2 on the newborn bacterial acute sinusitis was evaluated and the related mechanism was explored as well. First of all, the colony-forming unit (CFU) assay was conducted to measure the survival rate of the Streptococcus pneumoniae after compounds incubation. Besides, the enzyme linked immunosorbent assay (ELISA) detection kit was used to measure the levels of inflammatory cytokines released into the nasal mucus during newborn bacterial acute sinusitis after indicated treatment.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call