Abstract
To characterize retinal vessel whitening (RVW) in Retinitis Pigmentosa (RP). Single-center cross-sectional study. Review of clinical notes of clinically confirmed RP patients was performed followed by grading ultra-widefield imaging. Data collected included Best corrected visual acuity (BCVA), presence or absence and location of RVW and were correlated with disease. In total, 120 RP patients' charts were reviewed. Of these, 116 patients (232 eyes) were included in the final analysis with a mean age of 43.2 (39.8, 46.6) and a 1:1 male to female ratio. RVW was seen in either eye of 44 (38%) subjects, most frequently in the inferotemporal quadrant (p< 0.001). Total retinal thickness within the ETDRS area was significantly less in eyes with RVW (p<0.001), a mean difference of 151.7 µm. Both the inner and outer retina were thinner in the RVW group (p<0.001). There was also a significant association (p<0.04) between the number of quadrants of the retina affected by RVW and the reduction in retinal thickness. RVW is a common finding in RP, suggesting that it should be considered as a phenotypic feature of RP. RVW is also associated with structural changes to the central macula indicating its potential use as a marker of retinal disease severity.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call