Abstract
The retinal toxicity of chlorpromazine was studied in both albino and pigmented rats. In albino rats, the chronic administration of chlorpromazine (10 mg/kg po during 4 months) induced a large decrease in the amplitude of the electroretinogram (ERG) without detectable histological lesions. In pigmented rats (10 or 25 mg/kg for 6 months), despite a high concentration in ocular tissues, chlorpromazine did not induce functional ERG or histologic lesions. These data indicate that the ocular toxicity of chlorpromazine is not due to its affinity for melanin.
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