Abstract
Core-antigen vaccine technology has been available for the prevention of coliform mastitis for over ten years. However, unresolved issues regarding the most effective method to incorporate this technology into a dairy herd health program remain. These include number of vaccinations, effect of vaccinations on milk production of cows, and if risk factors associated with the incidence of clinical coliform mastitis correlate to vaccination schedules. This paper will discuss the immunological justification and limitations of vaccination protocols for coliform mastitis, and propose applications of this information.
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