Abstract
A pharmacoeconomic study of the rationality of the use of various chemotherapy regimens (“7 + 3” scheme) in the treatment of patients with acute forms of myeloid leukemia has been carried out. The use of the chemotherapy regimen “7 + 3” with 200 mg / m2 / per day dosage of cytarabine on 1-7 days allows to achieve a unit of treatment efficacy at a lower cost (CEA = 19.22 US $ / per unit of efficacy), compared with another dosage of cytarabine that was two times less, i.e., 100 mg / m² / day at the same period (CEA = US $ 20.18 / unit of effectiveness). The presented research results can be used in the formation of programs for the rational use of limited resources in the purchase of anticancer drugs for hematological cancer patients, as well as in the development of schemes for providing them with effective medical care in a hospital setting.
Highlights
According to the World Health Organization, leukemia occupies a leading position in the morbidity structure of the human lymphoid and hematopoietic systems [1-3]
Acute leukemias from the category of fatal diseases of the human hematopoietic system gradually moved to the category of diseases that could be treated, and the percentage of 5-year survival rate of oncogematological patients has steadily increased with each decade
As a result of pharmacoeconomical research, we determined the value of the ratio of total medical expenses when using remission induction schemes of the first line of chemotherapy to the effectiveness of its use in two groups of patients with acute myeloid leukemia
Summary
According to the World Health Organization, leukemia occupies a leading position in the morbidity structure of the human lymphoid and hematopoietic systems [1-3]. Specialists are concerned about the fact that leukemias occupy the first positions in the structure of morbidity and mortality from malignant pathologies among people under the age of 17 years [4-6] It is a wellknown fact, that this category of the population forms the socio-economic potential of any country, and the loss of patients under the age of 17 is an important demographic problem in any state and in society as a whole [7-8]. 1971), who in the last century successfully used in clinical practice the program of so-called "total therapy" in children [11-12] The use of these programs in the pathogenetic and symptomatic treatment of patients with acute leukemia allowed further specialists of the St. Jude hospital (St. Jude Children's Research Hospital, Memphis, USA) in 1979 to reach, and in the early 80-ies of the last century to cross the 50.0% threshold of survival of patients with acute forms of leukemia [13-15]. Acute leukemias from the category of fatal diseases of the human hematopoietic system gradually moved to the category of diseases that could be treated, and the percentage of 5-year survival rate of oncogematological patients has steadily increased with each decade
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