Abstract
We would like to reply to the letter by Drs Rose, Keating, and Backx,1 in which they gave their response to our recent publication in Circulation Research .2 In this study, we introduced alignment of transplanted stem cells as a novel determinant of functional integration of these cells with native cardiac tissue. In this study, we used neonatal rat mesenchymal stem cells (MSCs), which differentiated into functional cardiac cells after coculture with neonatal rat cardiomyocytes (CMCs). In their letter, Rose et al raise the important question of whether MSCs can differentiate into functional CMCs.1 However, we demonstrated that neonatal rat MSCs do differentiate into functional CMCs. Although we were one of the first to address the issue of cell alignment and stem cell transplantation, cardiomyogenic differentiation of MSCs …
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call