Abstract
Publisher Summary This chapter describes the response of the adrenergic system to changes in tissue and plasma levels of nerve growth factor (NGF). The immunoassay measures the biologically active β-subunit of mouse submaxillary gland NGF whether present in free form or in association with α- or γ-subunits in the 7S molecule. The method is called the two-site radioimmunoassay because of the sandwich that results from the two stages of the assay. Using this assay, the developmental changes in the tissues and plasma of mice were easily measured. The changes in the submaxillary glands agreed well with previously reported studies using the bioassay. The concentrations of NGF in submaxillary glands are controlled by circulatory sex hormones, with a marked difference in the concentrations between adult male and female mice. Gonadectomy reduces the NGF concentrations in the submaxillary glands of both sexes to very low levels which are restored to near normal male levels by testosterone treatment. The NGF content of submaxillary glands is very low in newborn mice and there is no sex related difference and this appears only after puberty.
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