Abstract
Publisher Summary This chapter discusses the extraneuronal uptake and metabolism in dog vascular structures. The role played by blood vessels in the removal and inactivation of circulating catecholamines has been emphasized. Extraneuronal uptake, however, appears to function as a vicarious process. Cocaine plus cortexone resulted in blockade of 91% of inactivation capacity in the SV, and of 54% in the MA. The differences observed are primarily attributed to the different patterns of innervation. Experiments in which the SV strips were previously labeled with 3 H-noradrenaline also show that extraneuronal uptake may play a role in the disposition of the transmitter, even in the presence of an intact innervation. In control conditions, normetanephrine appears to result from extraneuronal metabolization of noradrenaline released by electrical stimulation, because its formation is not affected by cocaine but is abolished by cortexone and on the contrary, DOPEG originates from the nerve terminals, as shown by the influence. The influence of the concentration of NA on the relative roles played by neuronal and extraneuronal uptake has been shown in the perfused dog hind limb.
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