Abstract
BackgroundExercise is one of the well‐known constituents to improve bone mass and to retain bone strength. Only few studies have reached the effects of resistive exercise on sclerostin levels, a protein that is thought to play a key role in orchestrating bone's mechanical adaptation. Sclerostin is produced and released by osteocytes and acts as an inhibitor of bone formation through inhibition of the Wnt/β‐catenin‐signaling pathway. The objective of this study was to evaluate acute and long‐term effects of exercise on bone biochemical marker expression. More specifically, we aimed to understand differences in the responses to resistance exercise with or without whole‐body vibration.MethodsA six week training intervention was performed including 26 healthy males (26 years, SD=4) in in a randomized parallel design. Performing either resistive exercise (RE, n=13) or resistive vibration exercise (RVE, n=13) training, with weekly increasing vibration frequencies 20–40 Hz. Serum samples were collected both at the initial and final exercise session. Changes in carboxy‐terminal cross‐linked telopeptide of type I collagen (sCTX‐I), as a marker of bone resorption, and of procollagen type I amino terminal propeptide (P1NP) as a specific marker of bone formation as well as serum sclerostin concentrations were measured via ELISA (sCTX‐I and sclerostin) or RIA (P1NP) measurements.ResultsSerum markers of sCTX‐I decreased by 15% within the first minutes following either training intervention, both regarding the initial and final training session. Subsequently, levels of sCTX‐I returned back to pre‐bout baseline after RE (time effect: P<0.001), and they depicted an overshoot by 18% after 75 min. Serum levels of P1NP depicted an acute increase by 15% to exercise (P<0.001). P1NP levels were non‐substantially increased in RE at the end of the 6 week intervention (P<0.001), but decreased by 10% in RVE, as compared to baseline (P< 0.001). Pre‐bout levels of sclerostin were marginally lowered at the end of the 6 week training phase. After the exercise bouts, sclerostin levels increased within the first minutes both RE and RVE (time effect: P<0.001). Notably, sclerostin responses to the initial exercise bouts differed significantly between RE and RVE P=0.029.ConclusionThe present findings suggest that in young healthy adults both conditions RE and RVE elicited an acute exercise‐induced bone resorption without any acute change in bone formation. Results are compatible with the idea that this response was mediated by sclerostin.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Published Version
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