Abstract
Exosomes are nanosized lipid vesicles released from cells. They are believed to contain proteins, lipids and nucleic acid cargos, and are capable of deliver their cargos to recipient cells, which in turn alter the expression of genes in neighboring cells. An increasing body of evidence indicates that they play a pivotal role in cell-to-cell communication, which is hijacked during various physiological and pathological conditions, such as myocardial damage, angiogenesis, cardiac remodeling and atherogenesis plaque formation. Further research of intercellular communication mediated by exosomes may potentially aid in the possible application of exosomes for biomarker discovery, curative effects, as well as prognosis of cardiovascular diseases, even the use of exosomes as a therapeutic drug delivery system on the basis of the exosome's ability to target specific cells, and transfer genetic materials.(Chin J Lab Med, 2015, 38: 439-441) Key words: Cardiovascular diseases; Exosomes; Signal transduction; Biological markers
Published Version
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