Advances in the application and detection of small dense low-density lipoprotein

Abstract

Regular checking blood lipids may be served as the important approach for the risk assessment and prevention of the atherosclerotic cardiovascular disease (ASCVD). It has been emphasized by several dyslipidemia management guidelines that the low density lipoprotein cholesterol (LDL-C) was the primary intervention target for prevention of ASCVD risk. Recent studies have demonstrated that small dense low density lipoprotein (sdLDL) or sdLDL cholesterol (sdLDL-C) levels as the biomarker for the prediction and risk assessment of ASCVD may be more sensitive than LDL-C. The isolation and detection methods of sdLDL or sdLDL-C were developed from the traditional ultracentrifugation or gel electrophoresis to the efficient, fast, accurate automated processing system. The continuous advances and popularization in analytical techniques of LDL subcomponents provided new methods and ideas for their application in the risk assessment and prevention of ASCVD.(Chin J Lab Med, 2017, 40: 417-420) Key words: Atherosclerosis; Cardiovascular disease; Lipoprotein, IDL