Abstract
Notch signaling pathway involves in cell differentiation process in a lot of tissues, especially playing an important role in T lymphocytes differentiation process. Recently, many reports have demonstrated that the Notch signaling pathway involves in the whole pathogenesis of bronchial asthma(BA) pathological process, including airway inflammation, airway hyperresponsiveness, airway remodeling and vascular remodeling of the airway. This paper summarizes the roles of Notch signaling pathway in BA and T lymphocyte regulation. Key words: Notch signaling pathway; T-lymphocyte; Asthma
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