Research progress of the protection mechanism of sevoflurane postconditioning to cerebral ischemia/reperfusion injury

Abstract

Background Cerebral ischemia/reperfusion injury(CI/RI) may be occur in the patients during subarachnoid hemorrhage, severe brain injury, cerebral infarction and hemorrhagic shock. Sevoflurane postconditioning which is in accordance with the pathophysiologic process in timing sequence and as a novel method of potential value for cerebral protection, have attracted extensive attention in recent years. Objective This paper reviewed the mechanisms of sevoflurane postconditioning against CI/RI. Content Phosphatidylinositol 3-kinase, protein kinase(PI3K/Akt), oxidativestress, mitochondrial ATP-sensitive potassium channel(mitoKATP), mitochondrial permeability transition pore(mPTP), extracellular signaling-regulated kinase 1/2(ERK1/2) are involved in neuroprotection by sevoflurane postconditioning under the setting of CI/RI. Trend To understand the mechanisms of sevoflurane postconditioning against CI/RI, and provide a theoretical basis for better treatment of CI/RI. Key words: Sevoflurane; Postconditioning; Cerebral; Ischemia/reperfusion injury; Protection mechanism