Research progress of strontium and alginate hydrogel in bone tissue engineering

Abstract

Oral and maxillofacial bone defects caused by inflammation, trauma, tumors, etc., are one of the common bone defects, and have always been a difficult point of clinical treatment which provides a major challenge for dentists. At present, the most effective treatment for bone defect is autologous bone transplantation, but there are problems such as limited source and increased patient suffering. Allogeneic bone is also effective in treating bone defects, but allogeneic bones also have many disadvantages, for example immune rejection and cross infection. Therefore, in order to solve the treatment problem of bone defects, bone tissue engineering came into being. Sodium alginate has the advantages of good biocompatibility and biodegradability, and is widely used in bone tissue engineering. Similarly, strontium which is also widely used in bone tissue engineering, has the functions of promoting osteogenesis and angiogenesis. However, there is no systematic discussion on these two aspects. This paper will summarize the research of strontium and alginate hydrogels in bone tissue engineering. Key words: Strontium; Sodium, alginates; Bone, tissue engineering; Bone regeneration; Hydrogels