Abstract
Clinical treatment of large segmental bone defect has always been a major challenge for the medical community, which is due to the complex and diverse pathogenic factors of large segmental bone defect.In recent years, the clinical treatment of large segmental bone defect has made great progress, and the main treatment options include vascularized or non-vascularized autologous bone grafts, allograft bone transplantation, masquelet technology, llizarov technology and bone tissue engineering.Therefore, understanding the advantages and disadvantages of various treatment options is very important for the clinical treatment of large bone defects in long bones, laying the foundation for clinical treatment. Key words: Large bone defect; Bone transplantation; Bone tissue engineering; Treatment progress
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